We are delighted to extend our warmest welcome to you for the International Symposium on Bioinformatics Research and Applications (ISBRA 2026), taking place in the captivating city of Macau. For years, ISBRA has stood as a leading global platform where researchers, developers, and practitioners in bioinformatics and computational biology come together to share pioneering ideas and research achievements.

This year's symposium invites the submission of original research spanning all areas of bioinformatics and computational biology. Topics of interest include, but are not limited to:

• Biomarker discovery
• Biomedical databases and data integration
• Biomedical text mining and ontologies
• Biomolecular imaging
• Comparative genomics
• Computational genetic epidemiology
• Computational proteomics
• Data mining and visualization
• Gene expression analysis
• Structural biology
• Genome analysis
• Systems biology

We encourage lively and constructive exchanges among diverse scholarly and practical contributions, fostering an environment of collaboration and innovation. Previous proceedings of ISBRA are accessible via https://link.springer.com/conference/isbra, reflecting the symposium's established academic legacy. We eagerly anticipate gathering with you at ISBRA 2026 to collectively propel the field forward and explore new horizons in bioinformatics applications.

We extend our sincere appreciation for your participation and wish you an inspiring, engaging, and memorable experience in Macau.